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American Society of Microbiology ABMM Sample Questions:

1. An outbreak of gastroenteritis occurs among attendees of a company picnic. Epidemiological investigation points towards contaminated potato salad. Stool cultures from affected individuals grow non-lactose fermenting, Gram-negative rods that are H2S positive on TSI agar. Which pathogen is most likely responsible?

A) Shigella sonnei
B) Salmonella Enteritidis
C) Enterotoxigenic E. coli (ETEC)
D) Vibrio cholerae

2. An immunocompromised patient develops a disseminated fungal infection. Blood cultures are consistently negative. However, a serum beta-D-glucan assay is markedly elevated. Tissue biopsy reveals the presence of hyaline, septate hyphae with dichotomous branching. The MOST likely causative organism is:

A) Cryptococcus neoformans
B) Aspergillus fumigatus
C) Rhizopus species
D) Mucor species

3. A patient with cystic fibrosis experiences a pulmonary exacerbation. Sputum culture grows a mucoid strain of Pseudomonas aeruginosa. The mucoid phenotype is primarily due to the overproduction of:

A) Pyocyanin
B) Elastase
C) Alginate
D) Exotoxin A

4. A laboratory worker sustains a needlestick injury while handling a blood sample known to be positive for Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg). The worker has completed the HBV vaccination series and has a documented anti-HBs titer >10 mIU/mL one month ago. What is the recommended post-exposure prophylaxis?

A) Hepatitis B vaccine booster dose only
B) No treatment required
C) Both HBIG and HBV vaccine booster dose
D) Hepatitis B immune globulin (HBIG) only

5. A patient with a history of inflammatory bowel disease is diagnosed with primary sclerosing cholangitis and undergoes liver transplantation. Post-transplant, they develop a bloodstream infection with a Gram-negative bacterium that is identified as Fusobacterium nucleatum. This organism's role in the pathogenesis of colorectal cancer is primarily attributed to its ability to:

A) Modulate the host immune response and promote a pro-inflammatory microenvironment.
B) Produce potent exotoxins that damage the intestinal epithelium.
C) Form biofilms that physically obstruct the bile ducts.
D) Directly induce mutations in colonic epithelial cells.

Solutions: